The Williams' sisters' return to competitive tennis as a duo is over before it started.

In their first Grand Slam doubles competition together in nearly four years, Serena, 44, and Venus were forced to withdraw from the Wimbledon doubles after the younger Serena's knee injury.

Serena was injured during her singles return earlier in the week — in a three-set loss.

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"I’m heartbroken to have to withdraw from doubles. Coming back to compete again has been a gift, and the opportunity to play alongside @venuswilliams once more meant the world to me. I did everything I could but unfortunately my knee just isn’t ready to compete," Serena said in an Instagram post.

The post included images of four syringes that Serena said "shows the fluid they drained from my knee after my singles match." An accompanying video showed her walking with strapping up and down her right leg and what appeared to be one of her daughters holding a cane for her.

However, with the U.S. Open approaching, Serena indicated she could play again somewhere else soon.

"All I can say," Serena said, "is stay tuned to a city near you."

RORY MCILROY TURNS HEADS AT WIMBLEDON BY SPORTING HIS MASTERS GREEN JACKET AT CENTER COURT

The Williams sisters — Venus is 46 — were scheduled to play Camila Osorio and Solana Sierra. It was the only first-round doubles match that wasn't scheduled earlier in the week, having been pushed back to give Serena more time to recover.

Serena was beaten 6-3, 6-7 (6), 6-3 by 20-year-old Maya Joint of Australia on Tuesday in her major return.

The Williams sisters are six-time champions as partners in women's doubles at Wimbledon. It was the first time they teamed up at Wimbledon since winning it in 2016. It was also the first time they had teamed up since the 2022 U.S. Open, which they lost in the first round.

Together, they have 14 grand slam titles, as well as three Olympic gold medals, as a team and never lost a final.

The Associated Press contributed to this report.

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The Williams' sisters' return to competitive tennis as a duo is over before it started.

In their first Grand Slam doubles competition together in nearly four years, Serena, 44, and Venus were forced to withdraw from the Wimbledon doubles after the younger Serena's knee injury.

Serena was injured during her singles return earlier in the week — in a three-set loss.

CLICK HERE FOR MORE SPORTS COVERAGE ON FOXNEWS.COM

"I’m heartbroken to have to withdraw from doubles. Coming back to compete again has been a gift, and the opportunity to play alongside @venuswilliams once more meant the world to me. I did everything I could but unfortunately my knee just isn’t ready to compete," Serena said in an Instagram post.

The post included images of four syringes that Serena said "shows the fluid they drained from my knee after my singles match." An accompanying video showed her walking with strapping up and down her right leg and what appeared to be one of her daughters holding a cane for her.

However, with the U.S. Open approaching, Serena indicated she could play again somewhere else soon.

"All I can say," Serena said, "is stay tuned to a city near you."

RORY MCILROY TURNS HEADS AT WIMBLEDON BY SPORTING HIS MASTERS GREEN JACKET AT CENTER COURT

The Williams sisters — Venus is 46 — were scheduled to play Camila Osorio and Solana Sierra. It was the only first-round doubles match that wasn't scheduled earlier in the week, having been pushed back to give Serena more time to recover.

Serena was beaten 6-3, 6-7 (6), 6-3 by 20-year-old Maya Joint of Australia on Tuesday in her major return.

The Williams sisters are six-time champions as partners in women's doubles at Wimbledon. It was the first time they teamed up at Wimbledon since winning it in 2016. It was also the first time they had teamed up since the 2022 U.S. Open, which they lost in the first round.

Together, they have 14 grand slam titles, as well as three Olympic gold medals, as a team and never lost a final.

The Associated Press contributed to this report.

Follow Fox News Digital’s sports coverage on X, and subscribe to the Fox News Sports Huddle newsletter.